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New Insight Into Biology, Molecular Diagnostics and Treatment Options of Unstable Carotid Atherosclerotic Plaque: a Narrative Review by Arkadiusz Migdalski; Arkadiusz Jawien is a Medicine article available to read on EtoBox.

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Indications for intervention in hemodynamically relevant carotid artery stenosis (carotid endarterectomy or stenting) are primarily based on a degree of stenosis and symptomatology. To date the plaque vulnerability is rarely taken into account in clinical decision making although development of molecular imaging allows a better understanding of plaque biology and provides new techniques detecting potentially vulnerable plaque at risk. A significant number of reports describing the mechanisms of unstable plaque formation suggest that it is a multifactorial process. Inflammation, lipid accumulation, apoptosis, proteolysis, the thrombotic process and angiogenesis are among the main factors of carotid plaque destabilization. Although inflammation is a key process in development of plaque vulnerability, the hemostasis and neoangiogenesis should be regarded as equally important. Only a small group of asymptomatic patients may benefit from the invasive treatment and it remains a challenge to determine whether initially asymptomatic carotid plaque become unstable or vulnerable. Currently, the main task of research on atherosclerotic lesion imaging is focused on functional state of the plaq

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Author

Arkadiusz Migdalski; Arkadiusz Jawien

Publisher

AME Publishing Company

Published

2021

Language

EN

Field

Medicine (Health Sciences)