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Tandem Mass Spectrometry for the Identification and Quantitation of Tryptolines (Tetrahydro-beta-carbolines) in Rat Brain Extracts by Johnson, Jodie Vincent, 1954- is a book available to read on EtoBox.

What is Tandem Mass Spectrometry for the Identification and Quantitation of Tryptolines (Tetrahydro-beta-carbolines) in Rat Brain Extracts about?

The natural occurrence of tryptolines in mammalian tissue is the subject of controversy. This is due to the lack of sensitivity and/or selectivity in the methods used for identification and the possibility of artefactual formation of tryptolines during sample preparation. Due to its excellent sensitivity and inherent selectivity, tandem mass spectrometry (MS/MS) has been used successfully for the direct analysis of complex mixtures for trace components with minimal, if any, sample clean-up. The triple quadrupole tandem mass spectrometer consists of, in series, a dual chemical ionization/electron impact ionization source, a quadrupole mass filter (Q1), a radio- frequency-only quadrupole (Q2), a second quadrupole mass filter (Q3), and an electron multiplier. In the analysis of an extract, methane positive or electron capture negative chemical ionization (PCI or NCI, respectively) of the extract produced ions characteristic of the components of the extract. The MS/MS quantitation in these (SRM) whereby the ion characteristic of a tryptoline is mass selected by i21 for fragmentation in Q2 through collisions with neutral gas molecules, and only the most abundant and characteristic daugh

Author

Johnson, Jodie Vincent, 1954-

Publisher

1984.

Published

1984

Language

EN