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Transdermal iontophoretic delivery of methylphenidate HCl in vitro by Parminder Singh; Sophia Boniello; Puchun Liu; Steven Dinh is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

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Methylphenidate is prescribed orally for Attention Deficit Disorder in children and adults, and for narcolepsy patients. Methylphenidate has a short plasma half-life (1 -2 h) and thus needs to be frequently administered for effective therapy. Such therapy has limitations in terms of patient compliance, particularly in young children. For such reasons, the development of a transdermal dosage form of methylphenidate may be useful. This study was undertaken to evaluate the passive and electrically assisted transport (iontophoresis) of methylphenidate from aqueous methylphenidate hydrochloride solutions across excised human skin. A maximum flux of 12.0 mg/(cm 2 h) of protonated methylphenidate was estimated from the passive transport data at pH 3.5. Iontophoresis significantly enhanced protonated methylphenidate transport as compared with passive delivery. From the present experiments, the efficiency of iontophoretic delivery of methylphenidate was approximately 700 mg/(mA h). Based on in vitro skin flux data, the daily dose of 15-40 mg methylphenidate can be achieved using a current density of 0.5 mA/cm 2 and a minimum transport area of 2-5 cm 2 for 24-h application, or an area of 4 -

Who reads Transdermal iontophoretic delivery of methylphenidate HCl in vitro?

Author

Parminder Singh; Sophia Boniello; Puchun Liu; Steven Dinh

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

1999

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)