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Non-HDL-C/TG ratio indicates significant underestimation of calculated low-density lipoprotein cholesterol (LDL-C) better than TG level: a study on the reliability of mathematical formulas used for LDL-C estimation by Agnieszka Ćwiklińska; Ewa Wieczorek; Anna Gliwińska; Marta Marcinkowska; Monika Czaplińska; Agnieszka Mickiewicz; Agnieszka Kuchta; Barbara Kortas-Stempak; Marcin Gruchała; Alicja Dębska-Ślizień; Ewa Król; Maciej Jankowski is a Medicine article available to read on EtoBox.

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## Abstract ## Objectives Low-density lipoprotein cholesterol (LDL-C) is the main laboratory parameter used for the management of cardiovascular disease. The aim of this study was to compare measured LDL-C with LDL-C as calculated by the Friedewald, Martin/Hopkins, Vujovic, and Sampson formulas with regard to triglyceride (TG), LDL-C and non-high-density lipoprotein cholesterol (non-HDL-C)/TG ratio. ## Methods The 1,209 calculated LDL-C results were compared with LDL-C measured using ultracentrifugation-precipitation (first study) and direct (second study) methods. The Passing-Bablok regression was applied to compare the methods. The percentage difference between calculated and measured LDL-C (total error) and the number of results exceeding the total error goal of 12% were established. ## Results There was good correlation between the measurement and calculation methods (r 0.962–0.985). The median total error ranged from −2.7%/+1.4% (first/second study) for Vujovic formula to −6.7%/−4.3% for Friedewald formula. The numbers of underestimated results exceeding the total error goal of 12% were 67 (Vujovic), 134 (Martin/Hopkins), 157 (Samspon), and 239 (Friedewald). Less than 7% of th

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Author

Agnieszka Ćwiklińska; Ewa Wieczorek; Anna Gliwińska; Marta Marcinkowska; Monika Czaplińska; Agnieszka Mickiewicz; Agnieszka Kuchta; Barbara Kortas-Stempak; Marcin Gruchała; Alicja Dębska-Ślizień; Ewa Król; Maciej Jankowski

Publisher

Walter de Gruyter GmbH

Published

2021

Language

EN

Field

Medicine (Health Sciences)