Can I read Hydrolytic (In)stability of Phosphate Isosteres on EtoBox?

Hydrolytic (In)stability of Phosphate Isosteres by Molhm Nassir; Avinoam Isaak; Bilha Fischer is a Chemistry article available to read on EtoBox.

What is Hydrolytic (In)stability of Phosphate Isosteres about?

For decades enzymatic hydrolysis of nucleotides, a cornerstone of life, was studied extensively along with the chemical hydrolytic reaction. The metabolic instability of nucleotides, in contrast with their enormous chemical stability, triggered development of metabolically stable phosphate isosteres. However, their chemical stability has not been reported. Here, we fill this gap by exploring the hydrolytic stability of the thiophosphate (PS) and dithiophosphate (PS) monoester isostere families. Kinetic experiments with uridine-PS and -PS (UMPS and UMPS) allow to chart their borders of stability. Furthermore, characterization of several chemical and structural features of UMPS and UMPS provide insights, which explain the dramatically different stability of PS or PS moieties at different positions of the nucleotide phosphate chain. Our conclusions may guide the broad scientific community that applies phosphate isosteres and allow the selection of optimal isosteres.

Who reads Hydrolytic (In)stability of Phosphate Isosteres?

Author

Molhm Nassir; Avinoam Isaak; Bilha Fischer

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Chemistry (Physical Sciences)