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Generation and Validation of an Antibody to Canine CD19 for Diagnostic and Future Therapeutic Purposes by Haran, Kumudhini Preethi; Lockhart, Alexandra; Xiong, Ailian; Radaelli, Enrico; Savickas, Patrick J.; Posey, Avery; Mason, Nicola J. is a Medicine article available to read on EtoBox.

What is Generation and Validation of an Antibody to Canine CD19 for Diagnostic and Future Therapeutic Purposes about?

The B-cell coreceptor, CD19 is a transmembrane protein expressed throughout B-cell ontogeny from pro–B cell to plasmablast. It plays an important role in B-cell development and function and is an attractive target for antibody-directed immunotherapies against B-cell malignancies, including acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), and non-Hodgkin lymphoma (B-NHL) in humans. With the rapid development of next-generation immunotherapies aimed at improving therapeutic efficacy, there is a pressing need for a clinically relevant, immune-competent, spontaneous animal model to derisk these new approaches and inform human immunotherapy clinical trials. Pet dogs develop spontaneous B-cell malignancies, including B-NHL and leukemias that share comparable oncogenic pathways and similar immunosuppressive features to human B-cell malignancies. Despite treatment with multiagent chemotherapy, durable remissions in canine B-NHL are rare and most dogs succumb to their disease within 1 year of diagnosis. Here we report the development and validation of an anti-canine CD19-targeting monoclonal antibody and its single-chain derivatives, which enable next-generation CD19-

Who reads Generation and Validation of an Antibody to Canine CD19 for Diagnostic and Future Therapeutic Purposes?

Author

Haran, Kumudhini Preethi; Lockhart, Alexandra; Xiong, Ailian; Radaelli, Enrico; Savickas, Patrick J.; Posey, Avery; Mason, Nicola J.

Publisher

American College of Veterinary Pathologists; SAGE Publications (ISSN 0300-9858)

Published

2020

Language

EN

ISBN

9780300985818

Field

Medicine (Health Sciences)