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GABA promotes survival and axonal regeneration in identifiable descending neurons after spinal cord injury in larval lampreys by Romaus-Sanjurjo, Daniel; Ledo-García, Rocío; Fernández-López, Blanca; Hanslik, Kendra; Morgan, Jennifer R.; Barreiro-Iglesias, Antón; Rodicio, María Celina is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is GABA promotes survival and axonal regeneration in identifiable descending neurons after spinal cord injury in larval lampreys about?
The poor regenerative capacity of descending neurons is one of the main causes of the lack of recovery after spinal cord injury (SCI). Thus, it is of crucial importance to find ways to promote axonal regeneration. In addition, the prevention of retrograde degeneration leading to the atrophy/death of descending neurons is an obvious prerequisite to activate axonal regeneration. Lampreys show an amazing regenerative capacity after SCI. Recent histological work in lampreys suggested that GABA, which is massively released after a SCI, could promote the survival of descending neurons. Here, we aimed to study if GABA, acting through GABAB receptors, promotes the survival and axonal regeneration of descending neurons of larval sea lampreys after a complete SCI. First, we used in situ hybridization to confirm that identifiable descending neurons of late-stage larvae express the gabab1 subunit of the GABAB receptor. We also observed an acute increase in the expression of this subunit in descending neurons after SCI, which further supported the possible role of GABA and GABAB receptors in promoting the survival and regeneration of these neurons. So, we performed gain and loss of function exp
Who reads GABA promotes survival and axonal regeneration in identifiable descending neurons after spinal cord injury in larval lampreys?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Romaus-Sanjurjo, Daniel; Ledo-García, Rocío; Fernández-López, Blanca; Hanslik, Kendra; Morgan, Jennifer R.; Barreiro-Iglesias, Antón; Rodicio, María Celina
- Publisher
- Nature Publishing Group; Springer Science and Business Media LLC; London: Nature Publishing Group, 2001- (ISSN 2041-4889)
- Published
- 2018
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)