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FGF21 alleviates endothelial mitochondrial damage and prevents BBB from disruption after intracranial hemorrhage through a mechanism involving SIRT6 by Runfeng Wang; Jin Wang; Zhiguo Zhang; Bo Ma; Shukai Sun; Li Gao; Guodong Gao is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is FGF21 alleviates endothelial mitochondrial damage and prevents BBB from disruption after intracranial hemorrhage through a mechanism involving SIRT6 about?

## Background Disruption of the BBB is a harmful event after intracranial hemorrhage (ICH), and this disruption contributes to a series of secondary injuries. We hypothesized that FGF21 may have protective effects after intracranial hemorrhage (ICH) and investigated possible underlying molecular mechanisms. ## Methods Blood samples of ICH patients were collected to determine the relationship between the serum level of FGF21 and the \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\Delta$$\end{document}ΔGCS%. Wild-type mice, SIRT6^flox/flox^ mice, endothelial-specific SIRT6-homozygous-knockout mice (eSIRT6^−/−^ mice) and cultured human brain microvascular endothelial cells (HCMECs) were used to determine the protective effects of FGF21 on the BBB. ## Results We obtained original clinical evidence from patient data identifying a positive correlation between the serum level of FGF21 and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepac

Who reads FGF21 alleviates endothelial mitochondrial damage and prevents BBB from disruption after intracranial hemorrhage through a mechanism involving SIRT6?

Author

Runfeng Wang; Jin Wang; Zhiguo Zhang; Bo Ma; Shukai Sun; Li Gao; Guodong Gao

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)