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An Audit of the Use of Granulocyte Colony-stimulating Factor in Septic Shock by D. P. Stephens; D. A. Fisher; B. J. Currie is a Medicine article available to read on EtoBox.

What is An Audit of the Use of Granulocyte Colony-stimulating Factor in Septic Shock about?

## Abstract __Background__: Granulocyte colony‐stimulating factor (G‐CSF) stimulates the production of neutrophils and modulates the function and activity of developing and mature neutrophils. In septic shock, the immune system can be considered one of the failing organ systems.G‐CSF improves immune function and may be a useful adjunctive therapy in patients with septic shock. __Aim__: To evaluate the introduction of G‐CSF as an adjunct to our standard treatment for community‐acquired septic shock. __Methods__: We performed a prospective data collection and analysis to determine whether the addition of G‐CSF to our standard treatment for community‐acquired septic shock was associated with improved hospital outcome, compared with an historical cohort ofsimilar patients. We included all patients admitted to the Intensive Care Unit (ICU) with community‐acquired septic shock between December 1998 and March 2000. Patients received 300 μg G‐CSF intravenously daily for 10 days in addition to ourstandard treatment for community‐acquired septic shock. G‐CSF was discontinued early if the patient was discharged from ICU before10 days or if the absolute neutrophil count exceeded 75 × 10^6^/mL.

Who reads An Audit of the Use of Granulocyte Colony-stimulating Factor in Septic Shock?

Author

D. P. Stephens; D. A. Fisher; B. J. Currie

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1444-0903)

Published

2002

Language

EN

Field

Medicine (Health Sciences)