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Can I read Inhibitors of multidrug resistance (MDR) have affinity for MDR substrates on EtoBox?
Inhibitors of multidrug resistance (MDR) have affinity for MDR substrates by Mire Zloh; Glenn W. Kaatz; Simon Gibbons is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Inhibitors of multidrug resistance (MDR) have affinity for MDR substrates about?
Multidrug-resistance (MDR) occurs in many bacterial species and tumour cells. MDR functions by membrane proteins which export drugs from cells, resulting in a low ineffective concentration of the drug. We have shown by molecular modelling that inhibitors of MDR have affinity for substrates of MDR transporters. This affinity may facilitate drug entry into cells and a large inhibitor-drug complex may be a poorer substrate for the MDR mechanism. This complex would effectively 'cloak' the drug rendering it unavailable for efflux.
Who reads Inhibitors of multidrug resistance (MDR) have affinity for MDR substrates?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Mire Zloh; Glenn W. Kaatz; Simon Gibbons
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2004
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)
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