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Artificial Perineurium to Enhance Nerve Recovery from Damage After Neurolysis by Nobuyuki Okui; Michiro Yamamoto; Yukako Fukuhira; Hiroaki Kaneko; Hitoshi Hirata is a Medicine article available to read on EtoBox.

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## Abstract We have developed a novel biodegradable poly‐lactide (PLA) film (honeycomb film) with a micropatterned porous structure on one side. We hypothesized that this film could be used as a substitute for perineurium. We used two types of thin PLA film: honeycomb film and cast film with smooth surfaces on both sides. In a rat extensive internal neurolysis model, the nerve was wrapped with honeycomb film (group H) or cast film (group CA), or left unwrapped (group C). Histological and functional analyses were performed. The honeycomb film closely attached to the nerve surface but did not adhere to surrounding tissues. In contrast, nerves in group C displayed severe adhesion to the neural bed. Mean percent wet muscle weight and motor nerve conduction velocity were significantly higher in group H than in group C. The honeycomb film prevents nerve adhesion and enhances functional recovery after extensive neurolysis. Muscle Nerve, 2010

Who reads Artificial Perineurium to Enhance Nerve Recovery from Damage After Neurolysis?

Author

Nobuyuki Okui; Michiro Yamamoto; Yukako Fukuhira; Hiroaki Kaneko; Hitoshi Hirata

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0148-639X)

Published

2010

Language

EN

Field

Medicine (Health Sciences)