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Can I read Synthesis of New 1,2,4-Trioxanes and their Antimalarial Activity on EtoBox?
Synthesis of New 1,2,4-Trioxanes and their Antimalarial Activity by Charles W. Jefford; Ernest C. McGoran; John Boukouvalas; Geoffrey Richardson; Brian L. Robinson; Wallace Peters is a Chemistry article available to read on EtoBox.
What is Synthesis of New 1,2,4-Trioxanes and their Antimalarial Activity about?
The three dihydronaphtho[l,2,4]trioxines e l l have been synthesized and two of them converted to the five carbamate and ester derivatives 12-16 (Schemes I and 2). The resulting new trioxanes together with two already known and ascaridole (7) were tested for antimalarial activity against the sensitive N strain of Plasmodium berghei in mice. On comparison with artemisinin (1) and dihydroartemisinin (2), modest activity was found. The four most active compounds were some 12-18 times less potent than 1. ') Artemisinin is also known as arteannuin and qinghaosu (QHS).
Who reads Synthesis of New 1,2,4-Trioxanes and their Antimalarial Activity?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Charles W. Jefford; Ernest C. McGoran; John Boukouvalas; Geoffrey Richardson; Brian L. Robinson; Wallace Peters
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0018-019X)
- Published
- 1988
- Language
- EN
- Field
- Chemistry (Physical Sciences)