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Can I read Synthesis and evaluation of delta lactams as nonpeptide HIV-protease inhibitors on EtoBox?
Synthesis and evaluation of delta lactams as nonpeptide HIV-protease inhibitors by George V. De Lucca is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis and evaluation of delta lactams as nonpeptide HIV-protease inhibitors about?
The cyclizatlon of the linear hydroxyethylene isostere based HIV-PR inhibitors gave the delta lactam XQ921, which was found to have a K i = 9.4 uM. It is proposed that a major reason for the weaker potency of the lactam XQ921 compared to cycliv urea based inhibitors is the lack of a PI' substituent that could interact with the S 1' pocket of HIV-PR.
Who reads Synthesis and evaluation of delta lactams as nonpeptide HIV-protease inhibitors?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- George V. De Lucca
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 1997
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)