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Pharmacological FMRI in the development of new analgesic compounds by Petra Schweinhardt; Chas Bountra; Irene Tracey is a Medicine article available to read on EtoBox.

What is Pharmacological FMRI in the development of new analgesic compounds about?

Chronic pain is a major problem for the individual and for society. Despite a range of drugs being available to treat chronic pain, only inadequate pain relief can be achieved for many patients. There is therefore a need for the development of new analgesic compounds. The assessment of pain depends to date entirely on the subjective report of the patient, in contrast to many other clinical conditions where biomarkers that help determine the severity and stage of the disease enable the physician to monitor the course of the disease and treatment effects longitudinally. In this article, we illustrate that magnetic resonance-based imaging techniques have the potential to provide sensitive and specific biomarkers of the pain experience, as well as clarifying disease mechanisms. Functional magnetic resonance imaging (FMRI) is particularly suited to investigating the effects of pharmacological agents on pain processing within the human central nervous system. Combination of FMRI and drug administration is termed pharmacological FMRI (phFMRI). In addition to outlining several methodological considerations that have to be taken into account when performing phFMRI, we discuss phFMRI studies

Who reads Pharmacological FMRI in the development of new analgesic compounds?

Author

Petra Schweinhardt; Chas Bountra; Irene Tracey

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0952-3480)

Published

2006

Language

EN

Field

Medicine (Health Sciences)