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Hypofractionated Conformal Radiotherapy in Carcinoma of the Prostate: Five-year Outcome Analysis by Jacqueline E Livsey; Richard A Cowan; James P Wylie; Ric Swindell; Graham Read; Vincent S Khoo; John P Logue is a Medicine article available to read on EtoBox.

What is Hypofractionated Conformal Radiotherapy in Carcinoma of the Prostate: Five-year Outcome Analysis about?

Purpose: Recent publications have indicated that the ␣/␤ ratios for carcinoma of the prostate are much lower than had originally been thought, suggesting that prostate cancer may be highly sensitive to fraction size. We have reviewed our unique experience of the use of 3.13 Gy fractions in a large cohort of men treated homogenously in a single institute. ## Methods and Materials : The outcome for 705 men with T1-T4, N0, M0 prostate cancer who received conformal radiotherapy between 1995 and 1998 at this center was analyzed. No patient received hormonal manipulation. Mean age was 68 years (range: 49 -84 years). Median pretreatment PSA was 13 ng/mL (range: 0.6 -270 ng/mL). Disease characteristics were as follows: Stage T1, 125 (18%); T2, 365 (52%); T3/4, 215 (30%); Gleason 2-6, 463 (66%); Gleason 7-10, 242 (34%); pretreatment PSA <10 ng/mL, 291 (41%); 10 to 20, 186 (27%). Median follow-up was 48 months (range: 1-82 months). Biochemical-free survival (bNED) was defined by the American Society for Therapeutic Radiology and Oncology consensus definition. Radiotherapy was delivered to a planning target volume (prostate plus all/base of the seminal vesicles dependent on risk criteria wit

Who reads Hypofractionated Conformal Radiotherapy in Carcinoma of the Prostate: Five-year Outcome Analysis?

Author

Jacqueline E Livsey; Richard A Cowan; James P Wylie; Ric Swindell; Graham Read; Vincent S Khoo; John P Logue

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2003

Language

EN

Field

Medicine (Health Sciences)