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Growth of Mammary Epithelial Cells in Breast-cancer Biopsies Correlates with Egf Binding by Eva Spitzer; Richard Grosse; Dieter Kunde; H. Eberhard Schmidt is a Medicine article available to read on EtoBox.
What is Growth of Mammary Epithelial Cells in Breast-cancer Biopsies Correlates with Egf Binding about?
In order to understand the role of EGF in the development of human mammary epithelial tissue, we analysed the binding of I2'1-EGF to sections of breast cancer biopsies. A mean specific '251-EGF binding of 8.9 fmol per mg protein was estimated in thin sections of 17 breast cancer biopsies. Microautoradiographic analysis of '2si-EGF binding to the tissue sections was applied to demonstrate that EGF was bound predominantly to mammary epithelial cells. The binding was clearly correlated to the number of mitoses of mammary epithelial cells in the same samples. The highest EGF binding and proliferation rates were found in biopsies from breast cancer with axillary lymph-node metastases. 4To whom reprint requests should be addressed.
Who reads Growth of Mammary Epithelial Cells in Breast-cancer Biopsies Correlates with Egf Binding?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Eva Spitzer; Richard Grosse; Dieter Kunde; H. Eberhard Schmidt
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1987
- Language
- EN
- Field
- Medicine (Health Sciences)