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What is Fraxetin Reduces Colitis Symptoms in Mice about?
The study investigates the protective effects of Fraxetin (Fxt) on dextran sulfate sodium-induced colitis in mice, demonstrating that Fxt significantly alleviates symptoms such as weight loss, colon length reduction, and tissue damage. Fxt was found to inhibit the activation of the NF-κB pathway and NLRP3 inflammasomes, reduce inflammation, and restore gut barrier function by enhancing goblet cell numbers and tight junction protein levels. Additionally, Fxt positively modulates the gut microbiota, suggestin
- Author
- 陳明楷
- Language
- EN