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Two-dimensional surface properties of an antimicrobial hydantoin at the air–water interface: An experimental and theoretical study by Abhishek Mandal; Ramya Santhana Gopala Krishnan; Sathiah Thennarasu; Satya Panigrahi; Asit Baran Mandal is a Materials Science article available to read on EtoBox.

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5,5-Acetamidomethyl-5-methylimidazolidine-2,4-dione shows antimicrobial activity against bacteria at millimolar concentrations well above its critical micellar concentration (cmc). Two-dimensional surface properties were investigated using Langmuir Film Balance to understand the membrane-active nature and nanomaterial behavior of this hydantoin derivative. Hydantoin forms an expanded nanofilm at air-water interface. The maximum limiting surface area (A(0)) and collapse pressure (pi(c)) are dependent on hydantoin concentration. Hydantoin undergoes a change in orientation at the interface, in the pressure region 2.5 and 7.5 mNm(-1), corresponding to surface areas 51-15 and 41-12A(2)molecule(-1), respectively. A large collapse pressure (pi(c)) in LB film indicates a role for hydrophobic interactions in the self-assembly of hydantoin. Surface areas computed using Connolly method, are in good agreement with the experimental results. Monolayer studies suggest a dispersed state for hydantoin when its concentration is below cmc, suggesting a mechanism for the observed bacteriostatic activity of hydantoin. In the present study, it has been found for the first time that the minimum inhibitor

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Author

Abhishek Mandal; Ramya Santhana Gopala Krishnan; Sathiah Thennarasu; Satya Panigrahi; Asit Baran Mandal

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0927-7765)

Published

2010

Language

EN

Field

Materials Science (Physical Sciences)