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Defining a Dose–response Relationship with Radiotherapy for Prostate Cancer: Is More Really Better? by Frank A Vicini; Anthony Abner; Kathy L Baglan; Larry L Kestin; Alvaro A Martinez is a Medicine article available to read on EtoBox.

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## Purpose: Data were reviewed addressing the association between radiation therapy (rt) dose and treatment outcome for localized prostate cancer to help clarify the existence of a potential dose-response relationship. ## Methods and materials: Articles were identified through the medline database, cancerlit database, and reference lists of relevant articles. studies were categorized into four groups based upon the endpoint analyzed, including biochemical control (bc), local control (lc), pathologic control (pc), and cause-specific survival (css). the impact of increasing rt dose with each endpoint was recorded. ## Results: Twenty-two trials involving a total of 11,297 patients were identified. of the 11 trials addressing the association of rt dose with lc, 9 showed statistically significant improvements. of the 12 trials that reported bc with rt dose, all showed statistically significant improvements. two out of 4 studies analyzing pc with increasing dose showed a positive correlation. finally, 3 out of 9 studies addressing rt dose with css showed statistically significant improvements. despite inconclusive results, patients with poor risk features (e.g., prostate-specific antigen

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Author

Frank A Vicini; Anthony Abner; Kathy L Baglan; Larry L Kestin; Alvaro A Martinez

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2001

Language

EN

Field

Medicine (Health Sciences)