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Can I read Tumor-Derived PD-L1^+^ Exosomes with Natural Inflammation Tropism for Psoriasis-Targeted Treatment on EtoBox?
Tumor-Derived PD-L1^+^ Exosomes with Natural Inflammation Tropism for Psoriasis-Targeted Treatment by Honglin Jia; Tao Liu; Qunfang Yang; Haiping Zheng; Shixiang Fu; Jiahui Hong; Zechen Zhou; Qingshan Huang; Zhaowei Zhang; Haigang Zhang; Xiaohong Chen; Renshan Sun; Wenjun Shan is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Tumor-Derived PD-L1^+^ Exosomes with Natural Inflammation Tropism for Psoriasis-Targeted Treatment about?
Psoriasis is a chronic inflammatory disease whose etiology is directly related to the dysregulation of cutaneous immune homeostasis. However, how to finely modulate the skin immune microenvironment to restore homeostasis remains an important challenge. Inspired by the natural attribute of tumor exosomes in the immune escape, the tumor-derived exosomes as an active targeting nanoplatform for the effective treatment of inflammatory skin disorder were first reported. As keratinocytes and immune cells express high PD-1 during the onset of psoriasiform skin inflammation, the PD-L1-positive exosomes derived from melanoma cells carrying pristimerin with extremely anti-inflammatory potential were yielded to treat psoriasis. The PD-L1 + exosomes carrying pristimerin were characterized, and the cellular uptake was performed to evaluate the PD-1 target capability. The anti-inflammatory action of PD-L1 + exosomes carrying pristimerin was observed in both in vitro and in vivo models of psoriasis. Our exosomes substantially increased pristimerin uptake with CD4 + T cells and keratinocytes, significantly inhibited the proliferation of Th17 cells, and promoted Treg differentiation in a psoriasis-l
Who reads Tumor-Derived PD-L1^+^ Exosomes with Natural Inflammation Tropism for Psoriasis-Targeted Treatment?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Honglin Jia; Tao Liu; Qunfang Yang; Haiping Zheng; Shixiang Fu; Jiahui Hong; Zechen Zhou; Qingshan Huang; Zhaowei Zhang; Haigang Zhang; Xiaohong Chen; Renshan Sun; Wenjun Shan
- Publisher
- American Chemical Society (ACS)
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)