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Hypophosphatasia: A Case of Two Patients With Spinal Cord Compression From Increase in Ligamentous Ossifications During Treatment by Michel Laroche; Guillaume Couture; Marie Faruch; Adeline Ruyssen‐Witrand; Valérie Porquet‐Bordes; Jean Pierre Salles; Yannick Degboe is a Medicine article available to read on EtoBox.

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## ABSTRACT Treatment with asfotase alfa has transformed the prognosis of hypophosphatasia in children and improves the bone and muscle signs in adults. The doses used in adults are the same as in children, whereas bone remodeling is different between them. We report on the cases of two patients treated with 1 mg/kg/day of asfotase alfa who developed spinal cord compression from spinal ossifications during treatment. The first patient, 50 years old, presented after 2 years of treatment with quadraparesis secondary to an increase in ossifications of the cervical vertebral ligaments. The neurological damage was resolved after laminectomy, and the patient was then treated for 18 months with doses of 80 mg per week, without recurrence of the bone and muscle signs. The second patient, 26 years old, 78 kg, developed pain and cervical stiffness with pyramidal tract irritation secondary to ossifications of the vertebral ligaments. This improved with a reduction of doses to 80 mg/week, which then, after 6 months of follow‐up, enabled maintained improvement of the bone and muscle pain that was initially obtained. To our knowledge, these are the first reported cases of increased spinal ligame

Who reads Hypophosphatasia: A Case of Two Patients With Spinal Cord Compression From Increase in Ligamentous Ossifications During Treatment?

Author

Michel Laroche; Guillaume Couture; Marie Faruch; Adeline Ruyssen‐Witrand; Valérie Porquet‐Bordes; Jean Pierre Salles; Yannick Degboe

Publisher

Wiley

Published

2021

Language

EN

Field

Medicine (Health Sciences)