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Correlation Between Acute and Late Toxicity in 973 Prostate Cancer Patients Treated With Three-Dimensional Conformal External Beam Radiotherapy by Barbara A. Jereczek-Fossa; Dario Zerini; Cristiana Fodor; Luigi Santoro; Flavia Serafini; Raffaella Cambria; Andrea Vavassori; Federica Cattani; Cristina Garibaldi; Federica Gherardi; Annamaria Ferrari; Bernardo Rocco; Epifanio Scardino; Ottavio de Cobelli; Roberto Orecchia is a Medicine article available to read on EtoBox.

What is Correlation Between Acute and Late Toxicity in 973 Prostate Cancer Patients Treated With Three-Dimensional Conformal External Beam Radiotherapy about?

Purpose: To analyze the correlation between acute and late injury in 973 prostate cancer patients treated with radiotherapy and to evaluate the effect of patient-, tumor-, and treatment-related variables on toxicity. Methods and Materials: Of the 973 patients, 542 and 431 received definitive or postprostatectomy radiotherapy, respectively. Three-dimensional conformal radiotherapy included a six-field technique and two-dynamic arc therapy. Toxicity was classified according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria. The correlation between acute and late toxicity (incidence and severity) was assessed. Results: Multivariate analysis showed that age #65 years (p = .06) and use of the three-dimensional, six-field technique (p 70 Gy (p = .014), and radiotherapy duration (p = .05) correlated with greater acute urinary toxicity. Acute rectal toxicity (p <.0001) was the only factor that correlated with late rectal injury on multivariate analysis. Late urinary toxicity correlated with acute urinary events (p <.0001) and was inversely related to the use of salvage radiotherapy (p = .018). A highly significant correlation was f

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Author

Barbara A. Jereczek-Fossa; Dario Zerini; Cristiana Fodor; Luigi Santoro; Flavia Serafini; Raffaella Cambria; Andrea Vavassori; Federica Cattani; Cristina Garibaldi; Federica Gherardi; Annamaria Ferrari; Bernardo Rocco; Epifanio Scardino; Ottavio de Cobelli; Roberto Orecchia

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2010

Language

EN

Field

Medicine (Health Sciences)