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Can I read Anti-prothrombin Antibodies Combined with Lupus Anti-coagulant Activity Is an Essential Risk Factor for Venous Thromboembolism in Patients with Systemic Lupus Erythematosus on EtoBox?
Anti-prothrombin Antibodies Combined with Lupus Anti-coagulant Activity Is an Essential Risk Factor for Venous Thromboembolism in Patients with Systemic Lupus Erythematosus by Junzo Nojima; Hirohiko Kuratsune; Etsuji Suehisa; Yoshiaki Futsukaichi; Hachiro Yamanishi; Takashi Machii; Teruo Kitani; Yoshinori Iwatani; Yuzuru Kanakura is a Medicine article available to read on EtoBox.
What is Anti-prothrombin Antibodies Combined with Lupus Anti-coagulant Activity Is an Essential Risk Factor for Venous Thromboembolism in Patients with Systemic Lupus Erythematosus about?
Anti‐prothrombin antibodies (anti‐prothrombin) and anti‐β2‐glycoprotein I antibodies (anti‐β2‐GP I) are the most common and characterized anti‐phospholipid antibodies (aPL) detected using specific enzyme‐linked immunosorbent assay (ELISA) systems. Recently, lupus anti‐coagulant (LA) activity detected by a phospholipid‐dependent coagulation assay was reported to be associated with anti‐prothrombin and/or anti–β2‐GP I. Here we show that the co‐existence of IgG anti‐prothrombin and LA activity might be an essential risk factor for venous thromboembolism (VTE) in patients with systemic lupus erythematosus (SLE). We examined not only the levels of antibodies to prothrombin and anti‐β2‐GP I (both IgG and IgM isotypes) using an ELISA system, but also LA activity detected using both diluted Russell's viper venom time (dRVVT) and STACLOT LA test in 124 patients with SLE. The SLE patients were divided into four groups according to the results of ELISA and LA assay results for each aPL: group A, ELISA^+^ and LA^+^ group B, ELISA^+^ and LA^−^; group C, ELISA^−^ and LA^+^ group D, ELISA^−^ and LA^−^. Regarding IgG anti‐prothrombin, the prevalence of VTE was significantly higher in group A (16/3
Who reads Anti-prothrombin Antibodies Combined with Lupus Anti-coagulant Activity Is an Essential Risk Factor for Venous Thromboembolism in Patients with Systemic Lupus Erythematosus?
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- Author
- Junzo Nojima; Hirohiko Kuratsune; Etsuji Suehisa; Yoshiaki Futsukaichi; Hachiro Yamanishi; Takashi Machii; Teruo Kitani; Yoshinori Iwatani; Yuzuru Kanakura
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)