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Analysis of expression patterns of IGF-1, caspase-3 and HSP-70 in developing human tooth germs by Darko Kero; Danijela Kalibovic Govorko; Ivana Medvedec Mikic; Katarina Vukojevic; Livia Cigic; Mirna Saraga-Babic is a Dentistry article available to read on EtoBox.

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## Aims: To analyze expression patterns of igf-1, caspase-3 and hsp-70 in human incisor and canine tooth germs during the late bud, cap and bell stages of odontogenesis. ## Materials and methods: Head areas or parts of jaw containing teeth from 10 human fetuses aged between 9th and 20th developmental weeks were immunohistochemically analyzed using igf-1, active caspase-3 and hsp-70 markers. semi-quantitative analysis of each marker's expression pattern was also performed. ## Results: During the analyzed period, igf-1 and hsp-70 were mostly expressed in enamel organ. as development progressed, expression of igf-1 and hsp-70 became more confined to differentiating tissues in the future cusp tip area, as well as in highly proliferating cervical loops. few apoptotic bodies highly positive to active caspase-3 were observed in enamel organ and dental papilla from the cap stage onward. however, both enamel epithelia moderately expressed active caspase-3 throughout the investigated period. ## Conclusions: Expression patterns of igf-1, active caspase-3 and hsp-70 imply importance of these factors for early human tooth development. igf-1 and hsp-70 have versatile functions in control of prol

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Author

Darko Kero; Danijela Kalibovic Govorko; Ivana Medvedec Mikic; Katarina Vukojevic; Livia Cigic; Mirna Saraga-Babic

Published

2015

Language

EN

Field

Dentistry (Health Sciences)