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Dose-reduced Conditioning for Allografting in 44 Patients with Chronic Myeloid Leukaemia: a Retrospective Analysis by Martin Bornhäuser; Michael Kiehl; Wolfgang Siegert; Johannes Schetelig; Bernd Hertenstein; Hans Martin; Rainer Schwerdtfeger; Herbert G. Sayer; Volker Runde; Nikolaus Kröger; Catrin Theuser; Gerhard Ehninger; the Cooperative German Transplant Study Group is a Medicine article available to read on EtoBox.
What is Dose-reduced Conditioning for Allografting in 44 Patients with Chronic Myeloid Leukaemia: a Retrospective Analysis about?
This retrospective study describes the outcome of patients with chronic myeloid leukaemia after allografting using dose‐reduced conditioning with fludarabine and busulphan. Forty‐four Philadelphia chromosome (Ph)‐positive patients were transplanted in nine German centres; 26 patients were in chronic phase, 11 in accelerated phase and seven in blast crisis. Thirty‐four patients achieved complete remission, with 18 alive and disease‐free at a median follow‐up of 562 d (range 244–922 d). Grade II–IV acute graft‐versus‐host disease (GVHD) incidence was 43%. Twenty patients died, 15 of causes unrelated to relapse. Risk factors predisposing to graft failure by univariate analysis were an unrelated donor (8/23 compared with a related donor 2/21, __P__ = 0·07) and interferon therapy within 90 d of transplant (4/6 versus 3/17, __P__ = 0·025). At the last follow‐up, of 31 patients for whom molecular or cytogenetic data were available, 16 (52%) were polymerase chain reaction‐negative, and seven (23%) were Ph‐negative by fluorescent __in situ__ hybridization. These findings demonstrate that dose‐reduced conditioning with fludarabine and busulphan provides durable engraftment and a low rate of
Who reads Dose-reduced Conditioning for Allografting in 44 Patients with Chronic Myeloid Leukaemia: a Retrospective Analysis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Martin Bornhäuser; Michael Kiehl; Wolfgang Siegert; Johannes Schetelig; Bernd Hertenstein; Hans Martin; Rainer Schwerdtfeger; Herbert G. Sayer; Volker Runde; Nikolaus Kröger; Catrin Theuser; Gerhard Ehninger; the Cooperative German Transplant Study Group
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)