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Coexistence of Factor V Leiden and Factor II A20210 Mutations and Recurrent Venous Thromboembolism by Giovanna D’Andrea; Donatella Colaizzo; Giuseppe Cappucci; Annamaria del Popolo; Vincenzo Brancaccio; Antonio Ciampa; Elvira Grandone; Giovanni Di Minno; Maurizio Margaglione is a Medicine article available to read on EtoBox.

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Summary Patients carrying the FV Leiden or the FII A20210 mutation have a high risk of venous thromboembolism. Among 542 patients with a documented diagnosis of deep venous thrombosis in one leg consecutively referred for a thrombophilic work-up, we have retrospectively assessed the rate of objectively documented previous recurrence in carriers of both FV Leiden and FII A20210 mutations. Eighty-two patients had experienced 115 episodes of recurrent venous thromboembolism. The rate of recurrent venous thromboembolism was 29.2% among subjects with and 14.5% in those without deficiencies of natural anticoagulant proteins (p = 0.055), and 24.6% among patients with and 14.0% in those without antiphospholipid antibodies (p = 0.036). The frequency of having a recurrent thromboembolism was 16.2%, 20.0%, and 36.4% among carriers of FV Leiden, FII A20210 mutation, or both gene defects, respectively, and 12.8% in subjects carrying neither mutation (p for trend = 0.004). When adjusted for age, sex, and thrombophilic risk factors, the rate was higher among patients with than in those without deficiencies of natural anticoagulant proteins (OR: 3.0; 95% CI: 1.2-7.5), aPL 2.5 (95% CI: 1.3-4.9), or

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Author

Giovanna D’Andrea; Donatella Colaizzo; Giuseppe Cappucci; Annamaria del Popolo; Vincenzo Brancaccio; Antonio Ciampa; Elvira Grandone; Giovanni Di Minno; Maurizio Margaglione

Publisher

Schattauer; Georg Thieme Verlag KG; Schattauer GmbH (ISSN 0340-6245)

Published

1999

Language

EN

Field

Medicine (Health Sciences)