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Can I read Meso ‐Aminomethyl‐BODIPY as a Scaffold for Nitric Oxide Photo‐Releasers on EtoBox?
Meso ‐Aminomethyl‐BODIPY as a Scaffold for Nitric Oxide Photo‐Releasers by Mikhail A. Panfilov; Tatyana Yu. Karogodina; Anastasiya A. Sibiryakova; Irina S. Tretyakova; Alexey Yu. Vorob'ev; Alexander E. Moskalensky is a Chemistry article available to read on EtoBox.
What is Meso ‐Aminomethyl‐BODIPY as a Scaffold for Nitric Oxide Photo‐Releasers about?
## Abstract Nitric oxide (NO) is a unique biochemical mediator involved in the regulation of vital processes. Its short lifetime in physiological conditions and local action impede direct application in medicine because highly targeted NO‐delivery systems are required. Light‐controllable NO releasers are promising for the development of smart therapies. Here we present simply prepared __meso__‐aminomethyl BODIPY (4,4‐difluoro‐4‐bora‐3a,4a‐diaza‐s‐indacene) derivatives containing __N__‐nitroso moiety, which show the photoinduced generation of NO in a solution. These compounds can additionally generate singlet oxygen, and NO/^1^O~2~ generation efficiency can be tuned by substituents. As an example of NO‐mediated effect, we demonstrate light‐dependent inhibition of platelet activation __in vitro__. The presented compounds could serve as the basis for the development of novel hybrid therapeutic methods.
Who reads Meso ‐Aminomethyl‐BODIPY as a Scaffold for Nitric Oxide Photo‐Releasers?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Mikhail A. Panfilov; Tatyana Yu. Karogodina; Anastasiya A. Sibiryakova; Irina S. Tretyakova; Alexey Yu. Vorob'ev; Alexander E. Moskalensky
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Chemistry (Physical Sciences)