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Can I read Gloxy: An oxygen‐sensitive coal for accurate measurement of low oxygen tensions in biological systems on EtoBox?
Gloxy: An oxygen‐sensitive coal for accurate measurement of low oxygen tensions in biological systems by Philip E. James; Oleg Y. Grinberg; Fuminori Goda; Tomasz Panz; Julia A. O'Hara; Harold M. Swartz is a Medicine article available to read on EtoBox.
What is Gloxy: An oxygen‐sensitive coal for accurate measurement of low oxygen tensions in biological systems about?
## Abstract This paper describes the characteristics of a new oxygen sensitive, paramagnetic material that has some significant advantages for measurements of tissue pO~2~ by __in vivo__ EPR. This paramagnetic component of Welsh coal, termed “gloxy” was found to have valuable EPR features that allow accurate measurement of low oxygen tensions __in vivo__; these include large oxygen‐dependent changes in linewidth, a high number of paramagnetic spin centers (resulting in high signal amplitude), and stability in tissue allowing repeated pO~2~, measurements to be made __in vivo__ with high precision. Renal pO~2~ was measured deep in the medulla region of isolated perfused kidneys and found to be lower than that in the cortex (1.7 ± 0.05 and 7.1 ± 0.3 mm Hg, respectively). The quality of the EPR signal obtained from the renal outer medulla and also from tumors in mice was such that the pO~2~ measurements were obtained with a precision of ±3% of the measured pO~2~ (__Kidney__: 1.7 ± 0.05 mmHg; __Tumor__: 1.37 ± 0.04 mmHg). __In vitro__ tests on the viability of cells and __in vivo__ studies using Gloxy demonstrate the stability and inertness of this oxygen‐sensitive material.
Who reads Gloxy: An oxygen‐sensitive coal for accurate measurement of low oxygen tensions in biological systems?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Philip E. James; Oleg Y. Grinberg; Fuminori Goda; Tomasz Panz; Julia A. O'Hara; Harold M. Swartz
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Health Sciences)