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This study investigates the effects of hypoxia on human stem cell-derived islets (SC-islets) and identifies that β cells experience a decline in identity and metabolic function under low oxygen conditions. The research highlights the role of the gene EDN3 in preserving β cell function and identity in hypoxic environments, providing insights into potential interventions for improving the efficacy of stem cell-derived islet therapies for type 1 diabetes. The findings suggest that understanding the molecular r

Author

Richard Ryder

Language

EN