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Ultrastructure of Proteoglycans in the Tectorial Membrane by Peter A. Santi; M. Kathryn Lease; Robert G. Harrison; Eileen M. Wicker is a Materials Science article available to read on EtoBox.

What is Ultrastructure of Proteoglycans in the Tectorial Membrane about?

The ultrastructure of proteoglycans (PGs) in the tectorial membrane (TM) of the mature chinchilla cochlea was investigated using the cationic dye Cuprolinic blue. When used at a high critical electrolyte concentration, Cuprolinic blue has been shown specifically to bind to the glycosaminoglycan residues of sulfated PGs. After Cuprolinic blue treatment, PGs were observed in the TM which were represented as rod-shaped, electron-dense structures. A perifibrillar, primarily orthogonal, array of PGs was associated with the type A protofibrils. These PGs were distributed in 50 nm intervals along the length of the type A protofibrils. A less common orientation was parallel to the axis of the type A protofibrils. PGs did not appear to be associated with the type B protofibrils. Based upon previous results by other investigators, the TM contains types I1 and IX collagen, and it appears likely that the type A protofibrils are composed of collagen type 11. PGs visualized in the TM in this study thus may represent the glycosaminoglycan residue of type IX collagen which is associated with the type I1 collagen fibrils. Alternatively, the TM PGs may be small dermatan or chondroitin sulfate PGs.

Who reads Ultrastructure of Proteoglycans in the Tectorial Membrane?

Author

Peter A. Santi; M. Kathryn Lease; Robert G. Harrison; Eileen M. Wicker

Publisher

Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0741-0581)

Published

1990

Language

EN

Field

Materials Science (Physical Sciences)