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Long-term lymphoid progenitors independently sustain naïve T and NK cell production in humans by Izotova, Natalia (author);Rivat, Christine (author);Baricordi, Cristina (author);Blanco, Elena (author);Pellin, Danilo (author);Watt, Eleanor (author);Gkazi, Athina S. (author);Adams, Stuart (author);Gilmour, Kimberly (author);Bayford, Jinhua (author);Booth, Claire (author);Gaspar, H. Bobby (author);Thrasher, Adrian J. (author);Biasco, Luca (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Our mathematical model of integration site data in clinical gene therapy supported the existence of long-term lymphoid progenitors capable of surviving independently from hematopoietic stem cells. To date, no experimental setting has been available to validate this prediction. We here report evidence of a population of lymphoid progenitors capable of independently maintaining T and NK cell production for 15 years in humans. The gene therapy patients of this study lack vector-positive myeloid/B cells indicating absence of engineered stem cells but retain gene marking in both T and NK. Decades after treatment, we can still detect and analyse transduced naïve T cells whose production is likely maintained by a population of long-term lymphoid progenitors. By tracking insertional clonal markers overtime, we suggest that these progenitors can support both T and NK cell production. Identification of these long-term lymphoid progenitors could be utilised for the development of next generation gene- and cancer-immunotherapies.

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Author

Izotova, Natalia (author);Rivat, Christine (author);Baricordi, Cristina (author);Blanco, Elena (author);Pellin, Danilo (author);Watt, Eleanor (author);Gkazi, Athina S. (author);Adams, Stuart (author);Gilmour, Kimberly (author);Bayford, Jinhua (author);Booth, Claire (author);Gaspar, H. Bobby (author);Thrasher, Adrian J. (author);Biasco, Luca (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)