Opening book details…
Can I read “Isogaba Maware”: quality control of genome DNA by checkpoints on EtoBox?
“Isogaba Maware”: quality control of genome DNA by checkpoints by Ana Kitazono; Tomohiro Matsumoto is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is “Isogaba Maware”: quality control of genome DNA by checkpoints about?
Checkpoints maintain the interdependency of cell cycle events by permitting the onset of an event only after the completion of the preceding event. The DNA replication checkpoint induces a cell cycle arrest until the completion of the DNA replication. Similarly, the DNA damage checkpoint arrests cell cycle progression if DNA repair is incomplete. A number of genes that play a role in the two checkpoints have been identified through genetic studies in yeasts, and their homologues have been found in fly, mouse, and human. They form signaling cascades activated by a DNA replication block or DNA damage and subsequently generate the negative constraints on cell cycle regulators. The failure of these signaling cascades results in producing offspring that carry mutations or that lack a portion of the genome. In humans, defects in the checkpoints are often associated with cancer-prone diseases. Focusing mainly on the studies in budding and fission yeasts, we summarize the recent progress.
Who reads “Isogaba Maware”: quality control of genome DNA by checkpoints?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ana Kitazono; Tomohiro Matsumoto
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0265-9247)
- Published
- 1998
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)