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Can I read Endosomal trafficking protein TBC‐2 modulates stress resistance and lifespan through DAF‐16‐dependent and independent mechanisms on EtoBox?
Endosomal trafficking protein TBC‐2 modulates stress resistance and lifespan through DAF‐16‐dependent and independent mechanisms by Annika Traa; Sonja K. Soo; Abdelrahman AlOkda; Bokang Ko; Christian E. Rocheleau; Jeremy M. Van Raamsdonk is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Endosomal trafficking protein TBC‐2 modulates stress resistance and lifespan through DAF‐16‐dependent and independent mechanisms about?
## Abstract The FOXO transcription factor, DAF‐16, plays an integral role in insulin/IGF‐1 signaling (IIS) and stress response. In conditions of stress or decreased IIS, DAF‐16 moves to the nucleus where it activates genes that promote survival. To gain insight into the role of endosomal trafficking in resistance to stress, we disrupted __tbc‐2__, which encodes a GTPase activating protein that inhibits RAB‐5 and RAB‐7. We found that __tbc‐2__ mutants have decreased nuclear localization of DAF‐16 in response to heat stress, anoxia, and bacterial pathogen stress, but increased nuclear localization of DAF‐16 in response to chronic oxidative stress and osmotic stress. __tbc‐2__ mutants also exhibit decreased upregulation of DAF‐16 target genes in response to stress. To determine whether the rate of nuclear localization of DAF‐16 affected stress resistance in these animals, we examined survival after exposure to multiple exogenous stressors. Disruption of __tbc‐2__ decreased resistance to heat stress, anoxia, and bacterial pathogen stress in both wild‐type worms and stress‐resistant __daf‐2__ insulin/IGF‐1 receptor mutants. Similarly, deletion of __tbc‐2__ decreases lifespan in both wil
Who reads Endosomal trafficking protein TBC‐2 modulates stress resistance and lifespan through DAF‐16‐dependent and independent mechanisms?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Annika Traa; Sonja K. Soo; Abdelrahman AlOkda; Bokang Ko; Christian E. Rocheleau; Jeremy M. Van Raamsdonk
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)