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Identification of Genetic Variants of Human Papillomavirus in a Group of Mexican HIV/AIDS Patients and Their Possible Association with Cervical Cancer by FELIPE ORTIZ-GUTIÉRREZ; LILIA SÁNCHEZ-MINUTTI; JOSÉ F. MARTÍNEZ-HERRERA; INDIANA D. TORRES-ESCOBAR; ELIAS B. PEZZAT-SAID; LUIS MÁRQUEZ-DOMÍNGUEZ; AMADO I. GRANDES-BLANCO is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Identification of Genetic Variants of Human Papillomavirus in a Group of Mexican HIV/AIDS Patients and Their Possible Association with Cervical Cancer about?
## Abstract Infections caused by the human immunodeficiency virus (HIV) and human papillomavirus (HPV) cause thousands of deaths worldwide each year. So far, there has been no consensus on whether there is a direct relationship between the incidence of neoplasms and the immunosuppression caused by HIV that could help understand if coinfection increases the likelihood of cervical cancer. The objective of the study was to identify the presence of genetic variants of HPV in a group of HIV-positive women and their possible association with cervical cancer. Cervical samples were taken from HIV-positive patients for cytological analysis to identify the HPV genotype by polymerase chain reaction (PCR) and sequencing. The most prevalent L1 capsid protein mutations in the HPV genotype were analyzed __in silico__. Various types of HPV were identified, both high-risk (HR) and low-risk (LR). The most prevalent genotype was HPV51. Analysis of the L1 gene sequences of HPV51 isolates showed nucleotide variations. Of the samples analyzed in Puebla, Mexico, HPV51 had the highest incidence (17.5%, 7/40). Different mutations, which could be used as population markers, were detected in this area, and t
Who reads Identification of Genetic Variants of Human Papillomavirus in a Group of Mexican HIV/AIDS Patients and Their Possible Association with Cervical Cancer?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- FELIPE ORTIZ-GUTIÉRREZ; LILIA SÁNCHEZ-MINUTTI; JOSÉ F. MARTÍNEZ-HERRERA; INDIANA D. TORRES-ESCOBAR; ELIAS B. PEZZAT-SAID; LUIS MÁRQUEZ-DOMÍNGUEZ; AMADO I. GRANDES-BLANCO
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)