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Epigenetic Mechanisms of Cadmium-induced Nephrotoxicity by Angela H. Guo; Surinder Kumar; David B. Lombard is a Environmental Science article available to read on EtoBox.

What is Epigenetic Mechanisms of Cadmium-induced Nephrotoxicity about?

Cadmium (Cd) is a widespread toxic pollutant that affects millions of individuals worldwide. Cd exposure in humans occurs primarily through consumption of contaminated food and water, cigarette smoking, and industrial applications. The kidney proximal tubular (PT) epithelial cells are the primary target of Cd toxicity. Cd-induced injury to PT cells impedes tubular reabsorption. Despite the many long-term sequelae of Cd exposure, molecular mechanisms of Cd toxicity are poorly understood, and no specific therapies exist to mitigate the effects of Cd exposure. In this review, we summarize recent work linking Cd-mediated damage to epigenetic perturbations — DNA methylation, and levels of histone modifications, including methylation and acetylation. New insights into the links between Cd intoxication and epigenetic damage will contribute to an improved understanding of Cd's pleiotropic impacts on cells, and perhaps lead to new, mechanism-based treatments for this condition.

Who reads Epigenetic Mechanisms of Cadmium-induced Nephrotoxicity?

Author

Angela H. Guo; Surinder Kumar; David B. Lombard

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Environmental Science (Physical Sciences)