Can I read Two Lipase-catalyzed Sequential Synthesis of Drug Derivatives in Organic Media on EtoBox?

Two Lipase-catalyzed Sequential Synthesis of Drug Derivatives in Organic Media by Bokai Liu; Xueqi Qian; Qi Wu; Xianfu Lin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Two Lipase-catalyzed Sequential Synthesis of Drug Derivatives in Organic Media about?

The study first reported the efficient lipase catalysis of aza-Markovnikov addition of N-heterocycles to vinyl esters in organic media. After screening the enzyme sources and organic solvents, the yield was up to 82.6% and the reaction rate increased more than 600-folds under the catalysis of Amino lipase M from Mucor javanicus in DMSO. Some control experiments were designed to demonstrate the catalytic specificity of lipase. A new strategy for the enzymatic synthesis of drug derivatives was developed by combining aza-Markovnikov addition with acylation procedure involving divinyl esters as linkers. A series of drug derivatives containing N-heterocycles were successfully obtained. The new activity of lipase expands the application of biocatalyst and provides a useful avenue to synthesize drug derivatives.

Who reads Two Lipase-catalyzed Sequential Synthesis of Drug Derivatives in Organic Media?

Author

Bokai Liu; Xueqi Qian; Qi Wu; Xianfu Lin

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0141-0229)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)