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Extended‐amygdala intrinsic functional connectivity networks: A population study by Samuel C. Berry; Richard G. Wise; Andrew D. Lawrence; Thomas M. Lancaster is a Neuroscience article available to read on EtoBox.

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Pre-clinical and human neuroimaging research implicates the extended-amygdala (ExtA) (including the bed nucleus of the stria terminalis [BST] and central nucleus of the amygdala [CeA]) in networks mediating negative emotional states associated with stress and substance-use behaviours. The extent to which individual ExtA structures form a functionally integrated unit is controversial. We utilised a large sample (n > 1,000 healthy young adult humans) to compare the intrinsic functional connectivity networks (ICNs) of the BST and CeA using task-free functional magnetic resonance imaging (fMRI) data from the Human Connectome Project. We assessed whether inter-individual differences within these ICNs were related to two principal components representing negative disposition and alcohol use. Building on recent primate evidence, we tested whether within BST-CeA intrinsic functional connectivity (iFC) was heritable and further examined co-heritability with our principal components. We demonstrate the BST and CeA to have discrete, but largely overlapping ICNs similar to previous findings. We found no evidence that within BST-CeA iFC was heritable; however, post hoc analyses found significan

Who reads Extended‐amygdala intrinsic functional connectivity networks: A population study?

Author

Samuel C. Berry; Richard G. Wise; Andrew D. Lawrence; Thomas M. Lancaster

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1065-9471)

Published

2020

Language

EN

Field

Neuroscience (Life Sciences)