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Silymarin and vitamin E reduce amiodarone-induced lysosomal phospholipidosis in rats by Márta Ágoston; Ferenc Örsi; Erzsébet Fehér; Krisztina Hagymási; Zsuzsa Orosz; Anna Blázovics; János Fehér; András Vereckei is a Environmental Science article available to read on EtoBox.
What is Silymarin and vitamin E reduce amiodarone-induced lysosomal phospholipidosis in rats about?
Several antioxidants have been shown to reduce lysosomal phospholipidosis, which is a potential mechanism of amiodarone toxicity, and prevent amiodarone toxicity by antioxidant and/or non-antioxidant mechanisms. The aim of this study was to test whether the co-administration of two structurally different antioxidants vitamin E and silymarin with amiodarone can reduce amiodarone-induced lysosomal phospholipidosis, and if yes, by reducing the tissue concentration of amiodarone and desethylamiodarone or by their antioxidant action. To this end, male Fischer 344 rats were treated by gavage once a day for 3 weeks and randomly assigned to the following four experimental groups: 1, control; 2, amiodarone (150 mg/(kg per day)); 3, amiodarone (150 mg/(kg per day)) plus vitamin E (100 mg/(kg per day)); 4, amiodarone (150 mg/(kg per day)) plus silymarin (60 mg/(kg per day)) treated groups. Total plasma phospholipid (PL), liver-conjugated diene, thiobarbituric acid reactive substances (TBARSs), amiodarone and desethylamiodarone concentrations were determined and the extent of lysosomal phospholipidosis in the liver was estimated by a semi-quantitative electron microscopic method. Amiodarone tr
Who reads Silymarin and vitamin E reduce amiodarone-induced lysosomal phospholipidosis in rats?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Márta Ágoston; Ferenc Örsi; Erzsébet Fehér; Krisztina Hagymási; Zsuzsa Orosz; Anna Blázovics; János Fehér; András Vereckei
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0300-483X)
- Published
- 2003
- Language
- EN
- Field
- Environmental Science (Life Sciences)