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Large-scale Testing of Human Serum to Determine Cytomegalovirus Neutralising Antibody by G. Leogrande; F. Merchionne; T. Lazzarotto; M.P. Landini is a Medicine article available to read on EtoBox.

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Complement (C')-dependent neutralising cytomegalovirus (CMV) antibody titres were determined in 415o serum samples obtained from infants and children, as well as women of childbearing age. In a smaller group of samples, C'-independent neutralising antibody titres were also measured together with their reactivity to each individual CMV structural polypeptide in addition to total CMV antibody concentration. Results showed that primary CMV infection takes place mainly in early infancy and that 30-4 ~ % women of childbearing age do not have any or have very low titres of CMV neutralising antibody. Since poor correlation was found between the results of neutralisation tests and those of enzyme immunoassay, routine testing of neutralising antibody is warranted in those subjects, such as pregnant women, at risk of CMV infection. Results of immunoblotting suggest a correlation between high titres of neutralising antibody and antibody reactivity with three proteins of MW 86, 65, 60 kDa.

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Author

G. Leogrande; F. Merchionne; T. Lazzarotto; M.P. Landini

Publisher

Elsevier Science; Elsevier ; W. B. Saunders Co., Ltd.; Elsevier BV (ISSN 0163-4453)

Published

1992

Language

EN

Field

Medicine (Health Sciences)