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Dapagliflozin attenuates diabetes-induced diastolic dysfunction and cardiac fibrosis by regulating SGK1 signaling by Seul-Gee Lee; Darae Kim; Jung-Jae Lee; Hyun-Ju Lee; Ro-kyung Moon; Yong-Joon Lee; Seung-Jun Lee; Oh-Hyun Lee; Choongki Kim; Jaewon Oh; Chan Joo Lee; Yong-ho Lee; Seil Park; Ok-Hee Jeon; Donghoon Choi; Geu-Ru Hong; Jung-Sun Kim is a Medicine article available to read on EtoBox.
What is Dapagliflozin attenuates diabetes-induced diastolic dysfunction and cardiac fibrosis by regulating SGK1 signaling about?
## Abstract ## Background Recent studies have reported improved diastolic function in patients administered sodium-glucose cotransporter 2 inhibitors (SGLT2i). We aimed to investigate the effect of dapagliflozin on left ventricular (LV) diastolic function in a diabetic animal model and to determine the molecular and cellular mechanisms underlying its function. ## Methods A total of 30 male New Zealand white rabbits were randomized into control, diabetes, or diabetes+dapagliflozin groups (n = 10/per each group). Diabetes was induced by intravenous alloxan. Cardiac function was evaluated using echocardiography. Myocardial samples were obtained for histologic and molecular evaluation. For cellular evaluation, fibrosis-induced cardiomyoblast (H9C2) cells were obtained, and transfection was performed for mechanism analysis (serum and glucocorticoid-regulated kinase 1 (SGK1) signaling analysis). ## Results The diabetes+dapagliflozin group showed attenuation of diastolic dysfunction compared with the diabetes group. Dapagliflozin inhibited myocardial fibrosis via inhibition of SGK1 and epithelial sodium channel (ENaC) protein, which was observed both in myocardial tissue and H9C2 cells. I
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- Author
- Seul-Gee Lee; Darae Kim; Jung-Jae Lee; Hyun-Ju Lee; Ro-kyung Moon; Yong-Joon Lee; Seung-Jun Lee; Oh-Hyun Lee; Choongki Kim; Jaewon Oh; Chan Joo Lee; Yong-ho Lee; Seil Park; Ok-Hee Jeon; Donghoon Choi; Geu-Ru Hong; Jung-Sun Kim
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)