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Fruit and Vegetable Consumption Interacts With HNF1A Variants on the C-Reactive Protein by Dayeon Shin; Kyung Won Lee is a Medicine article available to read on EtoBox.

What is Fruit and Vegetable Consumption Interacts With HNF1A Variants on the C-Reactive Protein about?

Epidemiological studies have demonstrated the inverse association between the intake of fruits and vegetables and inflammation. However, the mechanisms by which inflammation-related genes interact with fruit and vegetable intake and the role of these combinations in inflammation remain unclear. Therefore, we assessed the effect of interactions between fruit and vegetable intake and the hepatic nuclear factor 1 alpha (HNF1A) genetic variants on the C-reactive protein (CRP) levels. Baseline data from the Ansan and Ansung Cohort Study of the Korean Genome and Epidemiology Study (KoGES) were used. A total of 7,634 participants (3,700 men and 3,934 women) were included in the analyses. Fruit and vegetable intake was assessed using semi-quantitative food frequency questionnaire data. Genotyping information for HNF1A was extracted from the Affymetrix Genome-Wide Human SNP array 5.0. Inflammation was determined after overnight fasting by measuring CRP levels using automated analyzers. Multivariable logistic regression was used to estimate the adjusted odds ratio (AOR) with a 95% confidence interval (CI). In the fully adjusted model, men and women with the GG genotype of HNF1A rs2393791 and

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Author

Dayeon Shin; Kyung Won Lee

Publisher

Frontiers Media SA

Published

2022

Language

EN

Field

Medicine (Health Sciences)