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What is Celastrol Triggers Paraptosis in Cancer Cells about?

1) The study examines how the compound celastrol induces a type of cell death called paraptosis in cancer cells. 2) The researchers found that celastrol treatment increased mitochondrial calcium levels and ER stress in cancer cells. Inhibition of mitochondrial calcium uptake or IP3 receptor blocked celastrol-induced paraptosis. 3) The results suggest that celastrol triggers paraptosis by causing the release of calcium from the ER, which then enters mitochondria via the mitochondrial calcium uniporter, le

Author

Felipe Herrera Martínez

Language

EN