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Functional Connectivity as a Tool to Ascertain Language Localization in a Group of Children with Intractable Epilepsy by Byron Bernal; Magno R Guillen; Nolan Altman; Michael Duchowny is a Medicine article available to read on EtoBox.

What is Functional Connectivity as a Tool to Ascertain Language Localization in a Group of Children with Intractable Epilepsy about?

## Introduction: We investigated the relationship between lateralization indices based on the of Brodmann areas (BA) connectivity and language fMRI paradigms in a group of children with intractable epilepsy. ## Methodology: Intra-hemispheric ROI-to-ROI connectivity was assessed in 36 epileptic children (24 females) mean age 15.3 years, utilizing resting-state fMRI. Left vs right asymmetries were investigated between (1) BA pairs (pair-wise connectivity: PWC); (2) BA modules (global BA module connectivity: GBA); and (3) cerebral hemispheres (global hemispheric connectivity: GHC). Connectivity strength was graded in T scores (Z normalized values). Lateralization Index (LI) scores based on T values were obtained in all three assessments. Only LI with 2 SD above the mean were considered as significant lateralized pairs. Additionally, simple algebraic difference between left and right T values were obtained (TDIF). Results: Connectivity-related LI of significant pairs (predictors) were regressed against Language-fMRI-based LIs. Sensitivity and specificity of significant predictors were found. Interactions with demographics, seizure features, and neuropsychological scores were also perfo

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Author

Byron Bernal; Magno R Guillen; Nolan Altman; Michael Duchowny

Publisher

Acta Scientific Publications Pvt. Ltd.

Published

2021

Language

EN

Field

Medicine (Health Sciences)