Can I read The role of TLE1 in synovial sarcoma on EtoBox?

The role of TLE1 in synovial sarcoma by Sung Wook Seo; Hyewon Lee; Hyun‐Il Lee; Han‐Soo Kim is a Medicine article available to read on EtoBox.

What is The role of TLE1 in synovial sarcoma about?

## Abstract The treatment outcome of synovial sarcoma is poor owing to its resistance to radiation and chemotherapy. The Transducin‐like Enhancer of Split 1 (TLE1) is a co‐repressor that involves many signaling pathways like cell survival, hematopoiesis and differentiation. Although TLE1 is uniquely expressed in synovial sarcomas, the biological role of TLE1 is not completely understood. This study evaluated the function of TLE1 in synovial sarcomas using knock‐down of TLE1, and examined whether the inhibition of TLE1 suppresses the proliferation of synovial sarcomas and enhances the cytotoxicity caused by doxorubicin (doxo). The over‐expression of TLE1 was first confirmed in synovial sarcoma cells (HS‐SYII). When the HS‐SYII cells and normal fibroblast were transiently transfected with TLE1 siRNA, the MTT assay revealed growth inhibition in the HS‐SY‐11 cells but not in the normal fibroblast. TLE1 silencing also potentiated the cytotoxic effects of doxo against HS‐SYII cells. This effect of TLE1 silencing was attributed mainly to the induction of apoptosis. Subsequent analysis revealed that Bcl‐2 is a possible downstream target of TLE1 signaling. This study demonstrated that TLE1

Who reads The role of TLE1 in synovial sarcoma?

Author

Sung Wook Seo; Hyewon Lee; Hyun‐Il Lee; Han‐Soo Kim

Publisher

Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0736-0266)

Published

2011

Language

EN

Field

Medicine (Health Sciences)