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Evaluation of body mass index, pre-vaccination serum progesterone levels and anti-anthrax protective antigen immunoglobulin G on injection site adverse events following anthrax vaccination in women by Yujia Zhang; Stacey W. Martin; Charles E. Rose Jr; Raymond E. Biagini; Laura H. Franzke; Jerry P. Smith; Deborah L. Sammons; Shirley A. Robertson; Michael M. McNeil is a Medicine article available to read on EtoBox.

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## Abstract ## Background In 2002, CDC initiated the Anthrax Vaccination Program (AVP) to provide voluntary pre‐exposure anthrax vaccination for individuals at high risk for exposure to __Bacillus anthracis__ spores. The AVP offered an opportunity to investigate hypothesized reasons for a reported gender difference in injection site adverse events (AEs) following anthrax vaccine adsorbed (AVA). ## Objectives To evaluate in women the impact of body mass index (BMI), pre‐vaccination serum progesterone levels, and pre‐vaccination anti‐anthrax protective antigen immunoglobulin G concentrations (anti‐PA IgG) on the occurrence of AEs following subcutaneous AVA vaccination. ## Methods Participants' BMI was determined at enrollment. Also, pre‐vaccination blood samples were assayed for serum progesterone and anti‐PA IgG. Post‐vaccination solicited AEs were recorded by participants using a 4‐day diary card. ## Results Obese group had an elevated risk for arm soreness. Decreased pre‐vaccination serum progesterone level was associated with arm swelling. Increased pre‐vaccination anti‐PA IgG was associated with itching on the arm; and within the obese group, was associated with arm swelling, lu

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Author

Yujia Zhang; Stacey W. Martin; Charles E. Rose Jr; Raymond E. Biagini; Laura H. Franzke; Jerry P. Smith; Deborah L. Sammons; Shirley A. Robertson; Michael M. McNeil

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-8569)

Published

2008

Language

EN

Field

Medicine (Health Sciences)