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Relationship between disturbances of CO2 homeostasis and force output characteristics during isometric knee extension 1 1 Introduction 1 2 Methods 2 2.1 Participants 2 2.2 Experimental design 2 2.3 Preliminary experiment 2 2.4 Main experiment 2 2.5 Voluntary breathing and CO2 condition 2 2.6 Measurements and data processing 2 2.6.1 Knee extension force 2 2.6.2 Respiratory variables 3 2.7 Additional experiment 3 2.8 Statistical analysis 3 3 Results 4 3.1 Respiratory variables 4 3.2 MVC and force fluctuations 4 3.3 Relationships between Fcv and respiratory variables 4 3.4 Additional experiment 4 4 Discussion 4 4.1 Effects of difference in PETCO2 on Fcv - differences between CO2 conditions- 4 4.2 Effects of hypercapnia on Fcv 7 4.3 What is the mechanism of the positive correlation between PETCO2 and Fcv in the HYPER condition? 7 4.4 Study limitations and future directions 7 5 Conclusion 8 Funding 8 CRediT authorship contribution statement 8 Conflict of interest 8 Data Availability 8 Acknowledgments 8 References 8

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Language

UND

Category

nonfiction