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Indicators of suboptimal response to anti-tumor necrosis factor therapy in patients from China with inflammatory bowel disease: results from the EXPLORE study by Ji Li; Zhanju Liu; Pinjin Hu; Zhonghui Wen; Qian Cao; Xiaoping Zou; Yan Chen; Yingde Wang; Jie Zhong; Xizhong Shen; Dirk Demuth; Olga Fadeeva; Li Xie; Jun Chen; Jiaming Qian is a Medicine article available to read on EtoBox.
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## Abstract ## Background Prevalence of inflammatory bowel disease (IBD) is increasing in China. The EXPLORE study evaluated the incidence and indicators of suboptimal responses to first-line anti-tumor necrosis factor (TNF) in patients with ulcerative colitis (UC) or Crohn’s disease (CD). We present results for the mainland China subgroup. ## Methods A retrospective chart review was performed in adults with IBD at 10 centers in mainland China who initiated anti-TNF therapy between 01 March 2010 and 01 March 2015. The cumulative incidence of suboptimal response to first-line anti-TNF therapy was assessed over 24 months using the Kaplan–Meier method. Indicators of suboptimal response were: dose escalation, discontinuation, augmentation with non-biologic therapy, or IBD-related surgery/hospitalization. At site initiation, a survey was conducted with participating physicians to identify barriers to anti-TNF use. ## Results Of 287 patients (72% male) examined, 16/35 (45.7%) with UC and 123/252 (48.8%) with CD experienced a suboptimal response to first-line anti-TNF therapy at any point during the observation period (median 27.6 and 40.0 months, respectively). At 1 and 2 years post anti
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- Author
- Ji Li; Zhanju Liu; Pinjin Hu; Zhonghui Wen; Qian Cao; Xiaoping Zou; Yan Chen; Yingde Wang; Jie Zhong; Xizhong Shen; Dirk Demuth; Olga Fadeeva; Li Xie; Jun Chen; Jiaming Qian
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)