Can I read Safety of Selamectin in Dogs on EtoBox?

Safety of Selamectin in Dogs by M.J Novotny; M.J Krautmann; J.C Ehrhart; C.S Godin; E.I Evans; J.W McCall; F Sun; T.G Rowan; A.D Jernigan is a Immunology and Microbiology article available to read on EtoBox.

What is Safety of Selamectin in Dogs about?

Selamectin is a broad-spectrum avermectin endectocide for treatment and control of canine parasites. The objective of these studies was to evaluate the clinical safety of selamectin for topical use in dogs 6 weeks of age and older, including breeding animals, avermectin-sensitive Collies, and heartworm-positive animals. The margin of safety was evaluated in Beagles, which were 6 weeks old at study initiation. Reproductive, heartworm-positive, and oral safety studies were conducted in mature Beagles. Safety in Collies was evaluated in avermectin-sensitive, adult rough-coated Collies. Studies were designed to measure the safety of selamectin at the recommended dosage range of 6-12 mg kg -1 of body weight. Endpoints included clinical examinations, clinical pathology, gross and microscopic pathology, and reproductive indices. Selected variables in the margin of safety and reproductive safety studies were subjected to statistical analyses. Pups received large doses of selamectin at the beginning of the margin of safety study when they were 6 weeks of age and at their lowest body weight, yet displayed no clinical or pathologic evidence of toxicosis. Similarly, selamectin had no adverse e

Who reads Safety of Selamectin in Dogs?

Author

M.J Novotny; M.J Krautmann; J.C Ehrhart; C.S Godin; E.I Evans; J.W McCall; F Sun; T.G Rowan; A.D Jernigan

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0304-4017)

Published

2000

Language

EN

Field

Immunology and Microbiology (Life Sciences)