About this document
GPCRs in Heart Disease Therapy by amy is a document available to read on EtoBox.
The document discusses the role of G protein-coupled receptors (GPCRs) in heart disease. Specifically, it focuses on β-adrenergic receptors (βARs) which use β-arrestin dependent signaling to provide therapeutic benefits that delay heart failure after a myocardial infarction. βAR antagonists like carvedilol promote cardiomyocyte survival via β-arrestin mediated pathways. The document also examines GPCR signaling and desensitization, with a focus on signaling through βARs in the heart.
- Author
- amy
- Language
- EN