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Diagnostic value of circulating lncRNAs as biomarkers of digestive system cancers: A systematic review and meta-analysis by Fang, Xidong; Wang, Dongke; Pu, Ke; Zhang, Zhaoyu; Wang, Huiying; Wang, Haojia; Zheng, Ya; Wang, Yuping; Guan, Quanlin; Zhou, Yongning is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Diagnostic value of circulating lncRNAs as biomarkers of digestive system cancers: A systematic review and meta-analysis about?
## Objective: This meta-analysis aims to explore the diagnostic value and accuracy of circulating lncrnas as biomarkers of digestive system tumors. ## Methods: Pubmed, embase, cochrane library, and web of science were searched for relevant articles that were published before april 2019, and a meta-analysis was conducted. ## Results: 52 studies with 63 lncrnas were discussed in the meta-analysis. the pooled sensitivity and specificity of diagnosis were 0.80 (95% ci: 0.79-0.81) and 0.76 (95% ci: 0.75-0.77), respectively. the pooled dor (the diagnostic odds ratio) was 15.63 (95% ci: 12.77-19.12), and the overall auc (the area under the curve) was 0.87. besides, subgroup analyzes showed that the dor and auc of large sample sizes (>80), multiple lncrnas, serum-based lncrnas, and downregulation group were superior to those of small sample sizes (≤80), single lncrna, plasma-based lncrnas, and upregulation group, respectively. the current data also highlight that the diagnostic accuracy of circulating lncrnas in the case of colorectal cancer was higher than gastric cancer, hepatocellular carcinoma, esophageal carcinoma, and pancreatic cancer. and there is no difference in the perspective o
Who reads Diagnostic value of circulating lncRNAs as biomarkers of digestive system cancers: A systematic review and meta-analysis?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Fang, Xidong; Wang, Dongke; Pu, Ke; Zhang, Zhaoyu; Wang, Huiying; Wang, Haojia; Zheng, Ya; Wang, Yuping; Guan, Quanlin; Zhou, Yongning
- Publisher
- Expert Reviews; Informa UK (Taylor & Francis); Taylor & Francis; Informa UK Limited (ISSN 1473-7159)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)